All-Night, All-Day Allergy Relief! Works while you sleep & all the next day. Take Xyzal at night! It works to provide allergy symptom relief while you sleep, so you wake refreshed for a more productive day. Plus, it works faster than Claritin*, lasts up to 6x longer than Benadryl and, on first dose, provides the same relief as Zyrtec in a pill nearly half the size. Xyzal is the latest in OTC allergy relief*. Take it at night to relieve allergy symptoms while you sleep and get continuous relief that’s just as effective at hour 24 as at hour 1.